An observational multicentre retrospective analysis of 404 patients with chronic lymphocytic leukaemia was undertaken to determine which patients gain the maximum benefit from first-line FCR (fludarabine, cyclophosphamide, rituximab). Patients (28%) who carried mutated IGHV but neither 11q nor 17p deletion were considered to be low risk. Of these low-risk patients, 71% continued to be free of disease progression following treatment and the risk of relapse decreased after four years after receiving FCR.

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