DLBCL and Extranodal Disease

A re-evaluation of the clinical significance of extranodal disease among patients with diffuse large B-cell lymphoma (DLBCL) who were staged with positron emission tomography/computed tomography was undertaken to determine the prognostic impact of extranodal disease.


Results were presented at the 2014 American Society of Hematology annual meeting. Patients (n = 444) from Denmark and Canada were included in this retrospective study. Extranodal disease was diagnosed in 286 (64%) patients. Patients with one or two extranodal sites of involvement had a similar outcome: three-year progression-free survival was 68% versus 70%; patients with involvement of more than three extranodal sites had progressed.

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