Analysing Outcomes in MCL

An analysis of outcomes in patients with mantle cell lymphoma (MCL) following failure of first-line treatment was undertaken.

The study also evaluated the prognostic role of Secondary Mantle Cell Lymphoma Prognostic Index (sec MIPI). Findings were presented at the 2014 American Society of Hematology annual meeting. The analysis was undertaken in 388 patients with most having advanced disease. Following first-line treatment, there were 179 relapses or progressions and 70 deaths.

At the time of first relapse, the sec MIPI was low in 12.7% of patients; intermediate in 32.1% of patients and high in 59.8% of patients. Median progression-free survival (PFS) following initial diagnosis was 2.9 years but each subsequent relapse resulted in significantly shorter PFS.

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