Predicting Outcomes for MF/SS
Multiple prognostic variables were prospectively evaluated for 168 patients with advanced stage mycosis fungoides (MF) and Sézary syndrome (SS). Univariate analysis indicated that age, lymph node stage and serum lactate dehydrogenase (LDH) were significant for prognosis. Prognostic variables that were significantly associated with a worse overall survival were skin and node stage, age, large cell transformation and LDH. Patients receiving biologic response modifiers and histone deacetylase inhibitors first had a better survival (2.5 years) compared with those who received multi-agent chemotherapy (nine months). Read more here.