PET-CT and FL
Findings from a pooled analysis of central scan review in three multicentre studies showed that positron emission tomography/computed tomography (PET-CT) was more accurate than CT scanning when measuring response to first-line therapy in patients with follicular lymphoma (FL).
For this analysis data were taken from three multicentre prospective studies (the PRIMA study, the PET-Folliculaire study and the Fondazione Italiana Linfomi FOLL05 study). Scans from 246 patients who underwent both PET-CT and conventional CT scans were assessed. Of the patients with a positive PET scan, 23.2% (95% CI 11.1-37.9) were progression free at four years compared with 63.4% (55.9-70.0) who had a negative PET scan. When examining the response shown with conventional CT, it was seen to be weakly predictive of progression-free survival (HR 1.7 [95% CI 1.1-2.5]; p = 0.017). For more information, click here.